Debunking an old myth: Efficacy of Lithium treatment ist not diminished after disconinuation and reinitiation



Altrecht Institute for Mental Health Care, Utrecht.

Bipolar Disord. 2013 Aug 5. doi: 10.1111/bdi.12105. [Epub ahead of print]

The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness.


A recent Meta-Analysis found no convincing evidence for reduced efficacy of ltihium treatment in patients who had discontinued lithium medication and were then reinitiated with the same therapy compared to those who had contninously taken lithium.

This finding contradicts an old psychiatric “myth”  which suggested that “lithium does not work/ does not work as well in patients who have before discontinued the treatment.

Susceptibility genes are enriched in those of the HSV-1/host interactome in psychiatric and neurological disorders.



PolygenicPathways, Flat 2, 40 Baldslow Road, Hastings, East Sussex, TN34 2EY, UK.


Herpes simplex (HSV-1) can promote beta-amyloid deposition and tau phosphorylation, demyelination or cognitive deficits relevant to Alzheimer's disease or multiple sclerosis and to many neuropsychiatric disorders with which it has been implicated. Continue reading

Blood Tests may predict if you will respond to certain antidepressants



PLoS One. Published online July 17, 2013. Full article
and: MedScapePsychiatry

Scientists believe they have identified a metabolic signature that may help determine response to antidepressant treatment in patients with major depressive disorder (MDD). Continue reading