Glutamate-receptor autoantibodies in Schizophrenia


JAMA Psychiatry. 2013 Mar;70(3):271-8. doi: 10.1001/2013.jamapsychiatry.86.

Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis.

Autoantibodies angainst glutamate receptors are found in a high percentage of patients diagnosed with schizoprenia, especially in first diagnoses. They could contribute or even cause many symptoms in at least a part of all schizophrenia cases. Hoewever,  it is currently not common practice yet, to assess the presence of those antibodies in all first diagnosis cases of schizophrenia.